Modern Synthetic Approaches to Phthalonitriles with Special Emphasis on Transition-Metal Catalyzed Cyanation Reactions

作者：Martynov Alexander G^*; Birin Kirill P; Gorbunova Yulia G; Tsivadze Aslan Yu

来源：Macroheterocycles, 2013, 6(1): 23-32.

DOI：10.6060/mhc130221m

• Phthalonitriles
• transition metal catalyzed cyanation
• Rosenmund-Braun reaction
• alkoxy sustituted phthalonitriles
• tetracyanodibenzo-24-crown-8

Series of substituted phthalonitriles (4,5-bis[2'-(2 ''-benzyloxyethoxy) ethoxy]phthalonitrile, 4,5-bis(2-ethoxyethoxy)phthalonitrile and 4',5',4 '',5 ''-tetracyanodibenzo-24-crown-8) was obtained by means of Pd-catalyzed cyanation reaction in high yields. Analysis of the obtained results together with previously reported data concerning transition metal catalyzed synthesis of phthalonitriles and analogues reveals advantages of each of these methods in comparison with classical approaches - ammonolysis/dehydratation and Rosenmund-Braun cyanation.

• 出版日期2013