Schistosoma hemozoin and its possible roles

作者：Xiao Shu hua^*; Sun Jun^*

来源：International Journal for Parasitology, 2017, 47(4): 171-183.

DOI：10.1016/j.ijpara.2016.10.005

• Schistosoma
• Hematophagous habit
• Degradation of haemoglobin
• Hemozoin formation
• Iron source
• Artemether
• Quinolines
• Hemin

More than 95 years ago Schistosoma pigment had been deemed as a degradation product of haemoglobin. Until the 1950s, scientists initiated to pay attention to understand the hematophagous habit of schisto-somes, and to study the degradation of haemoglobin as well as the formation of hemozoin inside the gut of the worms. For a long time, the formation of hemozoin in both Plasmodium and in Schistosoma was considered to be the major route of heme detoxification, and hemozoin served a role in waste disposal. At the beginning of this century, the chemical structure of Schistosoma pigment was confirmed to be identical to that of malarial pigment (hemozoin) and its synthetic analogue, beta-hematin. Since then, studies on Schistosoma hemozoin have been investigated by some workers and the results showed that Schistosoma hemozoin may play important roles in pathogenicity, immune modulation, iron supply for egg formation, and interaction with some anti-schistosomal drugs. In this review, we briefly review and discuss the hematophagous habit of schistosomes, degradation of haemoglobin, formation of hemozoin in the worm gut, and possible roles of hemozoin.

• 出版日期2017-3
• 单位中国疾病预防控制中心; 中国疾病预防控制中心寄生虫病预防控制所; 同济大学