Association of rheumatoid arthritis susceptibility gene with lipid profiles in patients with rheumatoid arthritis

作者：Davis Lisa A^*; Whitfield Emily; Cannon Grant W; Wolff Roger K; Johnson Dannette S; Reimold Andreas M; Kerr Gail S; Richards J Steuart; Mikuls Ted R; Caplan Liron

来源：Rheumatology, 2014, 53(6): 1014-1021.

DOI：10.1093/rheumatology/ket472

• arthritis
• rheumatoid
• polymorphism
• single nucleotide
• cholesterol
• HDL
• LDL
• triglycerides

Objective. RA patients have an increased risk of cardiovascular (CV) disease, although the mechanisms are unclear. As RA and CV disease may be associated through lipid profiles, we examined whether single nucleotide polymorphisms (SNPs) associated with RA susceptibility were associated with low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglyceride (TG) levels in RA subjects. %26lt;br%26gt;Methods. Patients (n = 763) enrolled in the Veterans Affairs RA registry who were not on hydroxymethyl-glutaryl-CoA reductase inhibitor were genotyped for human leukocyte antigen shared epitope (HLA-DRB1-SE) and SNPs in the following genes: CTLA-4 (cytotoxic T-lymphocyte antigen 4), IL-10, PTPN22 (protein tyrosine phosphatase, non-receptor type 22), REL (c-Rel), STAT4 (signal transducer and activator of transcription protein), TNF-alpha and TRAF1 (TNF receptor-associated factor 1). Other covariates included patient characteristics (age, gender, race, smoking status, education, BMI, modified Charlson-Deyo comorbidity index), CV characteristics (hypertension, diabetes, alcohol abuse), pharmacologic exposures (MTX, anti-TNF, glucocorticoids) and RA severity/activity markers (RA disease duration, mean DAS, CRP, RF positivity, anti-CCP positivity). Multivariate linear regression was performed to determine the factors associated with LDL, HDL and TG levels. %26lt;br%26gt;Results. The REL SNP rs9309331 homozygous minor allele was associated with higher LDL levels. Caucasian race and increasing BMI were associated with lower HDL. Factors associated with higher TG were diabetes, Caucasian race and higher BMI. %26lt;br%26gt;Conclusion. The REL SNP rs9309331 was associated with LDL levels in our study. This association is a possible explanation of the increased risk of RA patients for CV disease and requires further inquiry.

• 出版日期2014-6