Drug delivery devices for retinal diseases

作者：Kaji Hirokazu^*; Nagai Nobuhiro; Nishizawa Matsuhiko; Abe Toshiaki

来源：Advanced Drug Delivery Reviews, 2018, 128: 148-157.

DOI：10.1016/j.addr.2017.07.002

• Biodegradable
• Intraocular implants
• Non-biodegradable
• Periocular implants
• Posterior segment of the eye
• Transscleral route

Retinal degenerative diseases are a leading cause of irreversible blindness and visual impairment, affecting millions of people worldwide. Although intravitreal injection can directly deliver drugs to the posterior segment of the eye, it is invasive and associated with serious side effects. The design of drug delivery systems targeting the posterior segment of the eye in a less invasive manner has still been challenging because of various anatomical and physiological barriers. In this review, we provide an overview of the current implant device-based approaches used for treating retinal degenerative diseases. We then offer our perspectives on future directions and challenges that remain for developing more effective device-based therapies for retinal diseases.

• 出版日期2018-3-15