An efficient synthesis of novel carbohydrate and thiosemicarbazone hybrid benzimidazole derivatives and their antimicrobial evaluation

作者：Panchal Shyamali N; Vekariya Rajesh H; Patel Kinjal D; Prajapati Shraddha M; Rajani Dhanji P; Rajani Smita D; Patel Hitesh D^*

来源：Indian Journal of Chemistry - Section B: Organic and Medicinal Chemistry , 2016, 55(5): 604-612.

• Antibacterial activity
• antifungal activity
• benzimidazole
• thiosemicarbazone
• carbohydrate
• microwave irradiation

A library of thiosemicarbazide hybrid 2-(aldo-polyhydroxyalkyl)benzimidazole derivatives have been designed and synthesized with simple and eco-friendly methodologies. The structures of the compounds have been elucidated with the aid of elemental analysis, IR, mass and H-1 NMR spectral data. These novel synthesized compounds have been evaluated for their antibacterial activity against two gram-positive bacteria (S. aureus and S. pyogenus) and two gram-negative bacteria (P. aeruginosa and E. coli). The title compounds have also been studied for their antifungal activity against C. albicans, A. niger and A. clavatus using the broth dilution technique.

• 出版日期2016-5