Agaricoglycerides Protect against Hepatic Ischemia/Reperfusion Injury by Attenuating Inflammatory Response, Oxidative Stress, and Expression of NF-kappa B

Zhao, Xiang-qian<sup>*</sup>; Liang, Bin; Liu, Yang; Huang, Xiao-qiang

doi:10.1155/2015/142736

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Agaricoglycerides Protect against Hepatic Ischemia/Reperfusion Injury by Attenuating Inflammatory Response, Oxidative Stress, and Expression of NF-kappa B

作者：Zhao, Xiang-qian^*; Liang, Bin; Liu, Yang; Huang, Xiao-qiang

来源：Evidence-Based Complementary and Alternative Medicine, 2015, 2015: 142736.

DOI：10.1155/2015/142736

摘要

We have investigated the effects of agaricoglycerides (AG) in a mouse model of hepatic I/R injury. I/R triggered increases/changes in markers of liver injury, hepatic oxidative stress, tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and nuclear factor kappa B (NF-kappa B). AG significantly reduced the extent of liver inflammation and oxidative stress and also attenuated the NF-kappa B activation as well as TNF-alpha and IL-1 beta production. Our results indicate that AG may represent a novel protective strategy against I/R-induced injury and inflammatory diseases.