A concise route to the highly-functionalized azetidine precursor: the enantioselective synthesis of penaresidin B

作者:Ding Feiqing; William Ronny; Kock Si Min; Leow Min Li; Liu Xue Wei*
来源:Chemical communications, 2015, 51(22): 4639-4642.
DOI:10.1039/c4cc09904d

摘要

An efficient and high-yielding synthesis of penaresidin B is disclosed herein. The concise 8-step synthesis of azetidine aldehyde was devised by incorporating our novel strategy for ready access to 3-amino-2,3-dideoxysugars via regio- and stereoselective tandem hydroamination/glycosylation of glycal as the key step.