Soy protein lowers cholestero without increasing bile acid excretion in subjects with moderate hypercholesterolemia

作者：Maki Kevin C^*; Butteiger Dustie N; Rains Tia M; Lawless Andrea L; Reeves Matthew S; Schasteen Chuck; Krul Elaine S

来源：Agro Food Industry Hi-Tech, 2011, 22(6): 14-16.

Soy protein (SP) has well-described cholesterol-lowering effects, but the mechanisms responsible are not well understood. We conducted a trial that evaluated the effects of 25 g/d of an insoluble fraction of SP or total milk protein (IMP) on fasting lipids and investigated the possible role of increased bile acid excretion in mediating these lipid responses. SP and IMP, respectively, reduced total cholesterol (-7.4 and -3.6 percent), low-density lipoprotein cholesterol (LDL-C) (-10.9 and -5.9 percent), and non-high-density lipoprotein cholesterol (-10.8 and -3.9 percent), (p < 0.05 for between group differences except LDL-C, p = 0.085). Fecal bile acid and neutral sterol excretion were not increased with either protein source. These findings confirm that SP has a hypocholesterolemic effect, but this does not appear to be attributable to increased fecal bile acid excretion.

• 出版日期2011-12