Development of recombinant cationic polymers for gene therapy research

作者：Canine Brenda F; Hatefi Arash^*

来源：Advanced Drug Delivery Reviews, 2010, 62(15): 1524-1529.

DOI：10.1016/j.addr.2010.04.001

• Gene delivery
• Targeted therapy
• Biopolymer
• Non-viral
• Bioinspired
• Fusion peptides
• Nanoparticles

Cationic polymers created through recombinant DNA technology have the potential to fill a void in the area of gene delivery. The recombinant cationic polymers to be discussed here are amino acid based polymers synthesized in E. coli with the purpose to not only address the major barriers to efficient gene delivery but offer safety, biodegradability, targetability and cost-effectiveness. This review helps the readers to get a better understanding about the evolution of recombinant cationic polymers; and the potential advantages that they could offer over viral and synthetic non-viral vectors for gene delivery. It also discusses some of the major challenges that must be addressed in future studies to turn recombinant polymers into clinically effective gene delivery systems. Recent advances with the biopolymer design suggest that this emerging new class of gene delivery systems has the potential to address some of the major barriers to efficient, safe and cost-effective gene therapy. Published by Elsevier B.V.

• 出版日期2010-12-30