Notch signaling in Drosophila long-term memory formation

作者：Ge XC; Hannan F; Xie ZL; Feng CH; Tully T; Zhou HM; Xie ZP; Zhong Y^*

来源：Proceedings of the National Academy of Sciences, 2004, 101(27): 10172-10176.

DOI：10.1073/pnas.0403497101

Notch (N) is a cell surface receptor that mediates an evolutionarily ancient signaling pathway to control an extraordinarily broad spectrum of cell fates and developmental processes. To gain insights into the functions of N signaling in the adult brain, we examined the involvement of N in Drosophila olfactory learning and memory. Long-term memory (LTM) was disrupted by blocking N signaling in conditional mutants or by acutely induced expression of a dominant-negative N transgene. In contrast, neither learning nor early memory were affected. Furthermore, induced overexpression of a wild-type (normal) N transgene specifically enhanced LTM formation. These experiments demonstrate that N signaling contributes to LTM formation in the Drosophila adult brain.

• 出版日期2004-7-6
• 单位清华大学