Adiponectin inhibits NLRP3 inflammasome by modulating the AMPK-ROS pathway

作者：Wang, Fang; Liu, Yuxing; Yang, Wenjun; Yuan, Jingjing; Mo, Zhaohui^*

来源：International Journal of Clinical and Experimental Pathology, 2018, 11(7): 3338-3347.

• Adiponectin
• NLRP3 inflammasome
• IL-1 ss
• IL-18
• AMPK

Chronic inflammation is a key contributor to obesity-related insulin resistance and type 2 diabetes (T2D). NLRP3 inflammasome activation plays an important role in impairing insulin signaling and insulin sensitivity. Adiponectin is an adipocyte-derived cytokine that has been shown to promote insulin sensitivity and exert anti-inflammatory properties, yet the detailed mechanism is still unclear. In this study, we aimed to investigate the anti-inflammatory effect of adiponectin on lipopolysaccharide (LPS) plus palmitic acid (PA)-induced THP-1 cells and to identify the underlying mechanism. We report here that adiponectin was able to inhibit interleukin (IL)-1 ss and IL-18 by suppressing NLRP3 inflammasome activation. Furthermore, we, for the first time, describe that adiponectin attenuates NLRP3 inflammasome activation by modulating the AMPK-ROS signaling pathway. These findings provide insight suggesting that adiponectin and NLRP3 inflammasome be considered molecular targets for the development of new treatment for T2D and the related metabolic diseases.

• 出版日期2018
• 单位中南大学