Short-term focal macular electroretinogram of eyes treated by aflibercept & photodynamic therapy for polypoidal choroidal vasculopathy

作者：Takayama Kei; Kaneko Hiroki^*; Kataoka Keiko; Ueno Shinji; Chang Hua Piao; Ito Yasuki; Terasaki Hiroko

来源：Graefes Archive for Clinical and Experimental Ophthalmology, 2017, 255(3): 449-455.

DOI：10.1007/s00417-016-3468-x

• Polypoidal choroidal vasculopathy
• Focal macular electroretinogram
• Photodynamic therapy
• Aflibercept

To compare short-term outcomes of intravitreal aflibercept injection (IAI) with or without initial photodynamic therapy (PDT) for polypoidal choroidal vasculopathy (PCV) using focal macular electroretinography (FMERG).
Observation case series.
Twelve patients (6 males, 6 females; 12 eyes) with na < ve PCV received 3 initial IAIs and a single session of PDT 3 days after the first IAI (combination group), and 13 patients (7 males, 6 females; 13 eyes) with na < ve PCV received 3 initial IAIs only (IAI group) were retrospectively observed. Changes in visual acuity, central retinal thickness (CRT), central choroidal thickness (CCT), and FMERG parameters (FMERGs) were compared.
The combination group showed improved visual acuity after the second and third IAI (P = 0.040, 0.019, respectively); both groups showed reduced CRT after the first IAI (P < 0.01, each). Only the combination group showed reduced CCT after the third IAI (P = 0.031). The FMERGs of the IAI group showed improved amplitudes of a-waves after the third IAI (P = 0.026) and of b-waves after the first and third IAI (P = 0.034, < 0.01, respectively); the combination group did not show improvement. The implicit times of the a- and b-waves were not changed in either group.
Combination therapy and IAI monotherapy each improved visual acuity and retinal structure to a similar degree; combination therapy reduced choroidal thickness but did not improve FMERGs in the short term.

• 出版日期2017-3