Association analysis of DISC1 gene polymorphisms with Attention-Deficit Hyperactivity Disorder in Iranian population

作者：Kayyal Matin; Movafagh Abolfazl^*; Hashemi Mehrdad; Sayad Arezou; Emamalizadeh Babak; Pourlran Khashayar; Kayyal Mohammadmoien; Amirabadi Mohammad Reza Eslami; Zamani Mahdi; Darvish Hossein

来源：Pakistan Journal of Medical Sciences, 2015, 31(5): 1162-1166.

DOI：10.12669/pjms.315.8132

• Association
• polymorphisms
• ADHD
• Hyperactivity
• DISC1 gene
• Iran

Background & Objectives: Attention deficit hyperactivity disorder (ADHD) is a common heritable psychiatric disorder with a worldwide prevalence of 5%. The etiology of ADHD is still incompletely understood, but several studies, consistently indicate the strong role of genetic factors on this disorder. The aim of this study was to determine the effect of three SNPs rs11122319, rs11122330 and rs6675281 in the etiology of ADHD in an Iranian children
Methods: In this research work, for the first time, we investigated the association of three SNPs (rs11122330, rs6675281 and rs11122319) in the DISCI gene with ADHD in Iranian population. Two hundred fourthy subjects composed of 120 patients and 120 healthy controls were included and tetra-primer ARMS PCR technique was used for genotyping all selected SNPs.
Results: We found differences in genotype and allele distributions of rs 6675281 polymorphism between our patients and controls. The A, T and A alleles were the more frequent alleles in rs11122319, rs6675281 and rs11122330 polymorphisms in both case and control groups respectively. The TT genotype was more frequent in control group compared to patients. (P value = 0.008, OR= 1.5837, 95% CI= 1.1012 to 2.2776).
Conclusion: Our findings strengthens the rote of DISCI gene as a susceptibility locus for ADHD and indicate that rs6675281 polymorphism is a susceptibility factor for ADHD for the first time in children reported in an Iranian population in this part of the world.

• 出版日期2015-10