Pexophagy and peroxisomal protein turnover in plants

作者：Young Pierce G; Bartel Bonnie^*

来源：Biochimica et Biophysica Acta-Molecular Cell Research, 2016, 1863(5): 999-1005.

DOI：10.1016/j.bbamcr.2015.09.005

• Autophagy
• LON protease
• Organelle quality control
• Peroxisome
• Pexophagy
• Protein degradation

Peroxisomes are dynamic, vital organelles that sequester a variety of oxidative reactions and their toxic byproducts from the remainder of the cell. The oxidative nature of peroxisomal metabolism predisposes the organelle to self-inflicted damage, highlighting the need for a mechanism to dispose of damaged peroxisomes. In addition, the metabolic requirements of plant peroxisomes change during development, and obsolete peroxisomal proteins are degraded. Although pexophagy, the selective autophagy of peroxisomes, is an obvious mechanism for executing such degradation, pexophagy has only recently been described in plants. Several recent studies in the reference plant Arabidopsis thaliana implicate pexophagy in the turnover of peroxisomal proteins, both for quality control and during functional transitions of peroxisomal content. In this review, we describe our current understanding of the occurrence, roles, and mechanisms of pexophagy in plants. This article is part of a Special Issue entitled: Peroxisomes edited by Ralf Erdmann.

• 出版日期2016-5