Downregulation of PPP2R5E expression by miR-23a suppresses apoptosis to facilitate the growth of gastric cancer cells

作者：Liu, Xue; Liu, Qian; Fan, Yajie; Wang, Shaohua; Liu, Xinrui; Zhu, Lihua; Liu, Min; Tang, Hua^*

来源：FEBS LETTERS, 2014, 588(17): 3160-3169.

DOI：10.1016/j.febslet.2014.05.068

• Phosphatase 2A
• PPP2R5E
• miR-23a
• Gastric cancer
• Tumorigenesis
• Apoptosis

PPP2R5E belongs to the phosphatase 2A regulatory subunit B family and acts as a tumor suppressor in human cancer. However, the role of PPP2R5E in the tumorigenesis of gastric cancer is unclear. Here, we declare that PPP2R5E is downregulated by miR-23a and induces cell growth inhibition and apoptosis in gastric cancer cells. Furthermore, ASO-miR-23a suppresses tumor growth derived from MGC803 cells in vivo. PPP2R5E is identified as a new target of miR-23a. Moreover, overexpression of PPP2R5E reversed the negative effects of miR-23a. We highlight the significance of miR-23a and PPP2R5E in the proliferation and apoptosis of gastric cancer cells.

• 出版日期2014-8-25
• 单位天津医科大学