Narcolepsy With Cataplexy as Presenting Symptom of Occult Neuroblastoma

作者：Sinsioco Claudine^*; Silver Kenneth; Forrest Katharine M; Gray Juliet; Nechay Alla; Sheldon Stephen; Schorr Ewa Chelmicka

来源：Pediatric Neurology, 2013, 49(1): 64-67.

DOI：10.1016/j.pediatrneurol.2012.12.038

Neuroblastoma associated with the paraneoplastic syndrome of opsoclonus-myoclonus is well-described. However, presentation with narcolepsy-cataplexy is not well-documented in the literature. Narcolepsy with cataplexy is also rare in children younger than 5 years of age. Here we describe three patients, each presenting in early childhood with complex neurological symptoms including narcolepsy with cataplexy that were subsequently found to have paraspinal neuroblastoma. In two of the cases, neurological symptoms resolved with treatment of the tumor and/or immunosuppression, but in one case, the child persistently had a devastating course despite complete resection of the tumor and aggressive immunosuppression. Published by Elsevier Inc.

• 出版日期2013-7
• 单位西北大学