Beyond genotype: serotonin transporter epigenetic modification predicts human brain function

作者：Nikolova Yuliya S^*; Koenen Karestan C; Galea Sandro; Wang Chiou Miin; Seney Marianne L; Sibille Etienne; Williamson Douglas E; Hariri Ahmad R

来源：Nature Neuroscience, 2014, 17(9): 1153-1155.

DOI：10.1038/nn.3778

We examined epigenetic regulation in regards to behaviorally and clinically relevant human brain function. Specifically, we found that increased promoter methylation of the serotonin transporter gene predicted increased threat-related amygdala reactivity and decreased mRNA expression in postmortem amygdala tissue. These patterns were independent of functional genetic variation in the same region. Furthermore, the association with amygdala reactivity was replicated in a second cohort and was robust to both sampling methods and age.

• 出版日期2014-9