Anti-oxidant and anti-acetylcholinesterase activities of Zygophyllum album

作者：Kchaou Mouna; Ben Salah Hichem; Mhiri Rania; Allouche Noureddine

来源：Bangladesh Journal of Pharmacology, 2016, 11(1): 54-62.

DOI：10.3329/bjp.v11i1.25463

<jats:p>&lt;p class="Abstract"&gt;The present study was carried out to explore the anti-acetylcholinesterase activity and anti-oxidant effect as well as content of phenolic compounds of various extracts from Zygophyllum album. It was observed that dichloromethane and ethanol extracts were endowed with a powerful anti-acetylcholinesterase activity with IC&lt;sub&gt;50&lt;/sub&gt; values of 40 and 58 µg/mL, respectively. These two extracts exhibited the highest DPPH radical scavenging activity (IC&lt;sub&gt;50&lt;/sub&gt;=0.2 mg/mL), the highest total anti-oxidant capacity (185.2 and 222.4 mg vitamin E/mg extract, respectively), the highest reducing power effect, and the highest β-carotene bleaching capacity. The findings showed that the extents of anti-acetylcholinesterase activity of Z. album extracts as well as their anti-oxidant capacity are in accordance with their phenolic contents. Hence, Z. album leaves would be useful against Alzheimer's disease.&lt;/p&gt;&lt;p&gt; &lt;/p&gt;&lt;p&gt;&lt;strong&gt;VIDEO CLIP&lt;/strong&gt;&lt;/p&gt;&lt;p&gt;&lt;a href="https://www.youtube.com/v/M03zi4Mzh6k"&gt;Determination of flavonoids content:&lt;/a&gt;  2 min 50 sec&lt;/p&gt;&lt;p&gt; &lt;/p&gt;</jats:p>

• 出版日期2016