Toll-like Receptor 9: AEP Takes Control

作者：van Endert Peter^*

来源：Immunity, 2009, 31(5): 696-698.

DOI：10.1016/j.immuni.2009.10.004

Toll-like receptor 9 (TLR9) requires proteolytic maturation to acquire signaling capacity; however, the involved protease(s) is unclear. In this issue of Immunity, Sepulveda et al. (2009) demonstrate that in dendritic cells, asparaginyl endopeptidase is a key protease that controls TLR9 maturation.

• 出版日期2009-11-20