Design, synthesis, and characterization of nucleosomes containing site-specific DNA damage

作者：Taylor John Stephen^*

来源：DNA Repair, 2015, 36: 59-67.

DOI：10.1016/j.dnarep.2015.09.025

• Histones
• Nucleosome
• Dinucleosome
• Chromatin
• Linker
• DNA damage
• DNA repair
• Photocaged
• DNA photoproducts
• AP sites
• Solid phase DNA synthesis

How DNA damaged is formed, recognized, and repaired in chromatin is an area of intense study. To better understand the structure activity relationships of damaged chromatin, mono and dinucleosomes containing site-specific damage have been prepared and studied. This review will focus on the design, synthesis, and characterization of model systems of damaged chromatin for structural, physical, and enzymatic studies.

• 出版日期2015-12