科研之友
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摘要
Ammonia in the tetrazole Ugi variation together with alpha-amino acid methyl ester-derived isocyanides provides tetrazolopiperidinones in good to high yields in one pot. The scope and limitations of this reaction were investigated by performing >70 reactions. The scaffold is useful to fill high-throughput screening decks and in structure based drug design.
- 出版日期2017-5
