Asymmetric addition of a nitrogen nucleophile to an enoate in the presence of a chiral phase-transfer catalyst: A novel approach toward enantiomerically enriched protected beta-amino acids

作者：Weiss Markus; Borchert Sonja; Remond Emmanuelle; Juge Sylvain; Groeger Harald

来源：Heteroatom Chemistry, 2012, 23(2): 202-209.

DOI：10.1002/hc.21004

A proof of concept for the asymmetric organocatalytic aza-Michael addition reaction of nitrogen nucleophiles with simple and readily available alkyl enoates as acceptor molecules in the presence of a chiral phase-transfer catalyst has been demonstrated. The desired enantiomerically enriched beta-amino acid derivatives were obtained in up to 86% yield and with enantioselectivities of up to 37% ee.

• 出版日期2012