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摘要
A series of new dimethyl-3,6-di(aryl)-1,4-dihydro-1,2,4,5-tetrazine-1,4-dicarboxylates were synthesised through an intermolecular cyclisation reaction of methyl N'-(alpha-chloro-substituted benzylidene) hydrazinecarboxylate and triethylamine. Their 1,4-dihydro-s-tetrazine structures were characterised by IR, H-1 NMR, MS, elemental analysis. Their antitumour activities were evaluated in vitro by the SRB method for A-549 cells and the MTT method for P-388 cells. The results show that none of the compounds had a high activity, but the substituents clearly had an effect on their antitumour activity.
- 出版日期2014-6
- 单位杭州医学院; 浙江工业大学
