Altered phosphate metabolism in HIV-1-infected patients with metabolic syndrome

作者：Grima Pierfrancesco^*; Guido Marcello; Chiavaroli Roberto; Stano Francesca; Tundo Paolo; Tana Mariangela; de Donno Antonella; Zizza Antonella

来源：Scandinavian Journal of Infectious Diseases, 2012, 44(2): 133-137.

DOI：10.3109/00365548.2011.623312

• HIV
• metabolic syndrome
• phosphate

Background: Metabolic syndrome (MS) represents a cluster of cardiovascular risk factors that has become a serious problem for HIV-1-infected patients. It has been proposed that disturbance of phosphate metabolism may represent a key feature of MS. Thus, we undertook the present study to investigate the relationship between phosphate levels and the presence of the characteristics of MS. Methods: One hundred and twenty-one HIV-1-infected patients were consecutively enrolled in a prospective, cross-sectional, single-centre study. Kidney tubular function was examined using tubular resorption of phosphate and normalized renal threshold phosphate concentration. Results: Univariate analysis showed that serum phosphate levels correlated negatively with systolic and diastolic blood pressure, glucose values, waist circumference, insulin, and triglycerides. Moreover, there was a positive relationship between phosphate and high-density lipoprotein (HDL) cholesterol. Multivariate analysis showed that insulin levels were correlated with serum phosphate concentration (r = -0.24, p = 0.01). Conclusions: Our data show that HIV-1-infected patients with MS have lower phosphate levels.

• 出版日期2012-2