Direct catalytic synthesis of densely substituted 3-formylpyrroles from imines and 1,4-ketoaldehydes

作者：Kumar Indresh^*; Mir Nisar A; Ramaraju Panduga; Singh Deepika; Gupta Vivek K; Rajnikant

来源：RSC Advances, 2014, 4(65): 34548-34551.

DOI：10.1039/c4ra06581f

A sustainable method for the direct access to highly substituted 3-formylpyrroles from 1,4-ketoaldehydes and imine via formal [3 + 2] cycloaddition is reported. This reaction involves a one-pot amine catalyzed chemoselective Mannich-cyclization-aerobic oxidation sequence with good to high yields. Further application of the gram scale reaction as well as synthesis of fully substituted 3-formylpyrrole is also shown.

• 出版日期2014