Drug Release Behavior of Polyurethane/Clay Nanocomposite: Film vs. Nanofibrous Web

作者：Saha Kasturi; Butola B S; Joshi Mangala^*

来源：Journal of Applied Polymer Science, 2014, 131(19): 40824.

DOI：10.1002/app.40824

• clay
• drug delivery systems
• electrospinning
• films
• polyurethanes

In the present study, polyurethane/clay nanocomposite films have been prepared by solvent casting method. Antiseptic drug chlorhexidine acetate was intercalated into montmorillonite clay and then incorporated into the polyurethane film. For comparison, the drug was also added directly into the polymeric dope used for film casting. In addition to that, nanofibrous web containing neat drug and drug loaded clay were fabricated using electrospinning technique. The emphasis of the study was on investigating the effect of drug intercalated into nanoclay vis-a-vis direct drug loading in the polymer on the drug release behaviour of polyurethane nanocomposite films as well as nanofibrous webs. The effect of morphology (film vs. nanofibrous web) on the drug release kinetics has also been discussed. It is observed that the nanoclay is acting as a sustained release carrier of drug, and nanofibrous web exhibits higher drug release rate as compared to the film.

• 出版日期2014-10-5