A population-based analysis of secondary malignancies in breast cancer patients receiving breast reconstruction

作者：Warschkow Rene; Cerny Thomas; Schmied Bruno M; Guller Ulrich; Thuerlimann Beat; Joerger Markus^*

来源：British Journal of Cancer, 2016, 115(1): 80-84.

DOI：10.1038/bjc.2016.108

• breast cancer
• surgery
• surveillance
• surveillance
• epidemiology and end results (SEER) database
• propensity score
• secondary malignancy

Background: There is an ongoing debate about the relationship between breast implants and secondary malignancies.
Methods: Breast cancer patients undergoing surgical reconstruction after mastectomy by either implants or autologous flap were identified in the Surveillance, Epidemiology and End Results registry between 1998 and 2002. The occurrence of secondary malignancies at least 1 year after diagnosis was compared between breast reconstruction with implants vs autologous flap.
Results: Of 7955 women, 3727 underwent reconstruction using implants and 4228 using autologous flap. The incidence of secondary tumours was similar in both the groups (hazards ratio (HR) = 1.02, 95% confidence interval (CI): 0.82-1.26, P = 0.880). For lung cancer, a significantly increased risk for implants (HR = 2.51, 95% CI: 1.28-4.95, P = 0.005) was observed.
Conclusions: Except for lung cancer, no association between implants and secondary malignancies including lymphomas was observed.

• 出版日期2016-6-28
• 单位河北医科大学