Systemic vascular response to brachial arteries crossclamping may prognosticate the outcome of remote ischemic preconditioning

作者：Vainer Boris G^*; Markel Arcady L

来源：Medical Hypotheses, 2015, 84(4): 298-300.

DOI：10.1016/j.mehy.2015.01.013

Remote ischemic preconditioning (RIPC) is a recent trend in cardiovascular medicine. From the literature, it may be deduced that physiological changes resulted from repeated episodes of brachial-cuff inflation/deflation during RIPC provoke, in some way, systemic "training" of the whole organism. At the same time, the effectiveness of such a "training" is substantially different in different humans, and the latter remains unclear. We propose the hypothesis as follows: the magnitude of real-time response of cardiovascular system to transient upper limb ischemia serves as a predictive indicator of the organismal sensitivity to RIPC preventive procedure and RIPC clinical efficiency in a particular person. The hypothesized prognosis of the RIPC-induced different resistance to post-ischemic reperfusion injury in different patients is represented in a quantitative manner using dynamic infrared examination of all human limbs simultaneously. With this screening method, it is clearly shown that different cohorts of healthy individuals exhibit different organismal responsiveness to upper limb arterial transient crossclamping. If proven, our hypothesis could have important implications for emergency medicine.

• 出版日期2015-4