A low body temperature on arrival at hospital following out-of-hospital-cardiac-arrest is associated with increased mortality in the TTM-study

作者：Hovdenes Jan; Roysland Kjetil; Nielsen Niklas; Kjaergaard Jesper; Wanscher Michael; Hassager Christian; Wetterslev Jorn; Cronberg Tobias; Erlinge David; Friberg Hans; Gasche Yvan; Horn Janneke; Kuiper Michael; Pellis Tommaso; Stammet Pascal; Wise Matthew P; Aneman Anders; Bugge Jan Frederik

来源：Resuscitation, 2016, 107: 102-106.

DOI：10.1016/j.resuscitation.2016.08.011

• Temperature management
• Cardiac arrest
• Body temperature on arrival at hospital

Aim: To investigate the association of temperature on arrival to hospital after out-of-hospital-cardiac arrest (OHCA) with the primary outcome of mortality, in the targeted temperature management (TTM) trial.
Methods: The TTM trial randomized 939 patients to TTM at 33 or 36 degrees C for 24 h. Patients were categorized according to their recorded body temperature on arrival and also categorized to groups of patients being actively cooled or passively rewarmed.
Results: OHCA patients having a temperature <= 34.0 degrees C on arrival at hospital had a significantly higher mortality compared to the OHCA patients with a higher temperature on arrival. A low body temperature on arrival was associated with a longer time to return of spontaneous circulation (ROSC) and duration of transport time to hospital. Patients who were actively cooled or passively rewarmed during the first 4 h had similar mortality. In a multivariate logistic regression model mortality was significantly related to time from OHCA to ROSC, time from OHCA to advanced life support (ALS), age, sex and first registered rhythm. None of the temperature related variables (included the TTM-groups) were significantly related to mortality.
Conclusion: OHCA patients with a temperature <= 34.0 degrees C on arrival have a higher mortality than patients with a temperature >= 34.1 degrees C on arrival. A low temperature on arrival is associated with a long time to ROSC. Temperature changes and TTM-groups were not associated with mortality in a regression model.

• 出版日期2016-10