MOXONIDINE INTO THE LATERAL PARABRACHIAL NUCLEUS MODIFIES POSTINGESTIVE SIGNALS INVOLVED IN SODIUM INTAKE CONTROL

作者：Gasparini S; Menani J V^*; Daniels D

来源：Neuroscience, 2015, 284: 768-774.

DOI：10.1016/j.neuroscience.2014.09.042

• parabrachial nucleus
• alpha(2)-adrenoreceptors
• postingestive
• sodium intake

The activation of alpha(2)-adrenoceptors with bilateral injections of moxonidine (alpha(2)-adrenoceptor and imidazoline receptor agonist) into the lateral parabrachial nucleus (LPBN) increases 1.8% NaCl intake induced by treatment with furosemide (FURO)+ captopril (CAP) subcutaneously. In the present study, we analyzed licking microstructure during water and 1.8% NaCl intake to investigate the changes in orosensory and postingestive signals produced by moxonidine injected into the LPBN. Male Sprague-Dawley rats were treated with FURO + CAP combined with bilateral injections of vehicle or moxonidine (0.5 nmol/0.2 mu l) into the LPBN. Bilateral injections of moxonidine into the LPBN increased FURO + CAP-induced 1.8% NaCl intake, without changing water intake. Microstructural analysis of licking behavior found that this increase in NaCl intake was a function of increased number of licking bursts from 15 to 75 min of the test (maximum of 49 +/- 9 bursts/bin, vs. vehicle: 2 +/- 2 bursts/bin). Analysis of the first 15 min of the test, when most of the licking behavior occurred, found no effect of moxonidine on the number of licks/burst for sodium intake (24 +/- 5 licks/burst, vs. vehicle: 27 +/- 8 licks/burst). This finding suggests that activation of alpha(2)-adrenoceptors in the LPBN affects postingestive signals that are important to inhibit and limit sodium intake by FURO+ CAP-treated rats.

• 出版日期2015-1-22