科研之友
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摘要
alpha-klotho, as an anti-aging protein, has been involved in a wide range of biological functions, especially in calcium, phosphate and vitamin D metabolism. Recent studies suggested that alpha-klotho plays important roles in female reproductive development, pregnancy, infant health and hormone related cancers. Effects of alpha-klotho include anti-oxidation, promoter methylation, histone deacetylation and IGF, FGF, Wnt signaling pathways transduction. In this paper, we provide a seminal view on recent advances in understanding the behavior of alpha-klotho in female productive health, primarily focusing on the gaps in current research that underline insights into its function and mechanism, and suggest a new avenue for systematic future research.
- 出版日期2017
- 单位武汉大学
