Neuromagnetic high-frequency oscillations correlate with seizure severity in absence epilepsy

作者：Tang, Lu; Xiang, Jing; Huang, Shuyang; Miao, Ailiang; Ge, Huaiting; Liu, Hongxing; Wu, Di; Guan, Qingshan; Wu, Ting; Chen, Qiqi; Yang, Lu; Lu, Xiaopeng; Hu, Zheng; Wang, Xiaoshan^*

来源：Clinical Neurophysiology, 2016, 127(2): 1120-1129.

DOI：10.1016/j.clinph.2015.08.016

• Magnetoencephalography
• Childhood absence epilepsy
• High frequency oscillations

Objective: This study quantified the clinical correlation of interictal and ictal neuromagnetic activities from low- to very-high-frequency ranges in childhood absence epilepsy (CAE). @@@ Methods: Twelve patients with clinically diagnosed drug-naive CAE were studied using a 275-channel whole-head magnetoencephalography (MEG) system. MEG data were digitized at 6000 Hz and analyzed at both sensor and source levels with multi-frequency analyses. @@@ Results: Neuromagnetic changes from interictal to ictal periods predominantly occurred in medial prefrontal cortex and parieto-occipito-temporal junction in absence seizures. The changes were statistically significant in low- frequency bands only (< 30 Hz, p < 0.0001). There was a significant correlation between the source strength of ictal high-frequency oscillations (HFOs) in 200-1000 Hz and the number of daily seizures (r = 0.734, p < 0.01). @@@ Conclusions: CAE has focal neuromagnetic sources. The transition from interictal to ictal periods is associated with the elevation of low- frequency brain activities. The strength of HFOs reflects the severity of absence seizures. @@@ Significance: Low-and high-frequency MEG signals reveal distinct brain activities in CAE. HFOs is a new biomarker for the study of absence seizures.

• 出版日期2016-2
• 单位南京医科大学