Aldosterone stimulates the proliferation of uterine leiomyoma cells

作者：Isobe Aki; Takeda Takashi^*; Wakabayashi Atsuko; Tsuiji Kenji; Li Bin; Sakata Masahiro; Yaegashi Nobuo; Kimura Tadashi

来源：Gynecological Endocrinology, 2010, 26(5): 372-377.

DOI：10.3109/09513590903511521

• Aldosterone
• angiotensin II
• signal transduction
• mineralocorticoid receptor
• uterine leiomyoma

Study design. This study investigated the potential role of aldosterone in the proliferation of ELT-3 leiomyoma cells.
Results. Aldosterone-induced ELT-3 leiomyoma cell proliferation and the expression of mineralocorticoid receptor (MR) were confirmed. Pre-incubating the cells with the MR blockers spironolactone or eplerenone effectively repressed aldosterone-induced and angiotensin II (Ang II)-induced cell proliferation. Treatment of aldosterone increased the levels of Ang II type-1 receptor mRNA.
Conclusion. These experimental findings in vitro show the presence of complex regulation of Ang II and aldosterone induced leiomyoma cell proliferation.

• 出版日期2010-5