SOCS1 in cancer: An oncogene and a tumor suppressor

作者：Beaurivage Claudia; Champagne Audrey; Tobelaim William S; Pomerleau Veronique; Menendez Alfredo; Saucier Caroline^*

来源：Cytokine, 2016, 82: 87-94.

DOI：10.1016/j.cyto.2016.01.005

• SOCS1
• Cytokine
• Cancer
• Tumor suppressor
• Oncogene
• Colorectal cancer

The Suppressor Of Cytokine Signaling 1 (SOCS1) has been extensively investigated in immune cells where it works as a potent inhibitor of inflammation by negative feedback regulation of the cytokine-activated JAK-STAT signaling pathways. SOCS1 is also recognized as a tumor suppressor in numerous cancers and its critical functional relevance in non-immune cells, including epithelial cells, has just begun to emerge. Most notably, conflicting results from clinical and experimental studies suggest that SOCS1 may function as either a tumor suppressor or a tumor promoter, in a cell context-dependent manner. Here, we present an overview of the mechanisms underlying SOCS1 function as a tumor suppressor and discuss the emerging evidences of SOCS1 activity as an oncogene.

• 出版日期2016-6