Association between p53 codon 72 polymorphism and sarcoma risk among Caucasians

作者：Chang Zhengqi; Yu Xiuchun^*

来源：Tumor Biology, 2014, 35(5): 4807-4812.

DOI：10.1007/s13277-014-1631-8

• Meta-analysis
• p53 codon 72
• Sarcoma
• Polymorphism
• Risk

Many published data on the association between p53 codon 72 polymorphism and sarcoma risk showed inconclusive results. The present study was designed to derive a more precise estimation of this connection among Caucasians. We conducted a literature search in PubMed, EMBASE, Web of Science, and CNKI databases for case-control studies examining the association between p53 codon 72 polymorphism and sarcoma risk. The meta-analysis was performed using STATA 12.0 software. Crude odds ratios (ORs) with corresponding 95 % confidence intervals (CIs) were used to measure the strength of any association. The results of this meta-analysis did not provide statistical evidence for significant sarcoma risk associated with p53 codon 72 polymorphism (ORArg/Arg vs. Pro/Pro = 1.00, 95 % CI = 0.80-1.26, P (heterogeneity) = 0.980; ORArg/Arg + Arg/Pro vs. Pro/Pro = 0.99, 95 % CI = 0.83-1.19, P (heterogeneity) = 0.990; ORArg/Arg vs. Arg/Pro + Pro/Pro = 1.09, 95 % CI = 0.89-1.35, P (heterogeneity) = 0.532; ORallele Arg vs. allele Pro = 1.03, 95 % CI = 0.90-1.18, P (heterogeneity) = 0.883; ORArg/Pro vs. Pro/Pro = 0.95, 95 % CI = 0.71-1.27, P (heterogeneity) = 0.919). We also did not find significant links in further subgroup analyses by ethnicity, control source, and sarcoma type. The present meta-analysis of currently available data suggests that the p53 codon 72 polymorphism may not play a role in sarcoma development in Caucasians.

• 出版日期2014-5