Annulation of Thiolmidates and Vinyl Carbodiimides to Prepare 2-Aminopyrimidines, Competent Nucleophiles for Intramolecular Alkyne Hydroamination. Synthesis of (-)-Crambidine

作者：Perl Nicholas R; Ide Nathan D; Prajapati Sudeep; Perfect Hahdi H; Duron Sergio G; Gin David Y^*

来源：Journal of the American Chemical Society, 2010, 132(6): 1802-+.

DOI：10.1021/ja910831k

A convergent synthesis of(-)-crambidine is reported. The sequence Capitalizes on two novel key transformations, including.(I) a [4+2] annulation of thioimidates with vinyl carbodiimides and an alkyne hydroamination employing 2-aminopyrimidine nucleophiles.

• 出版日期2010-2-17