Apolipoprotein E knockout induced inflammatory responses related to microglia in neonatal mice brain via astrocytes

作者：Liu Yimei; Xu Xiaohua; Dou Hongbo; Hua Ying; Xu Jinwen; Hui Xu^*

来源：International Journal of Clinical and Experimental Medicine, 2015, 8(1): 737-743.

• Apolipoprotein E
• mice
• cerebral palsy
• inflammatory responses

More and more evidences suggestted that ApoE plays an important role in modulating the systemic and central nervous inflammatory responses. However, there is a lack of exacted mechanism of ApoE. In this study, we aimed to investigate whether apolipoprotein E (ApoE) induced inflammatory responses and apoptosis in neonatal mice brain from ApoE deficient (ApoE(-/-)) and wildtype (WT). Compared to control group, the microglia cell from ApoE(-/-) mice showed more severe inflammation and cell death such as iNOS and IL-1 beta. Furthermore, anti-inflammatory such as TGF-beta, IL-10 from microglia and astrocytes in ApoE(-/-) mice were decreased. On the other way, TGF-beta from astrocytes can inhibit inflammation factors secretion from microglia. Our findings suggested that the anti-inflammation factor such as IL-10 mainly from microglia and TGF-beta mainly from astrocyte is significant decreased after Loss of ApoE function in ApoE(-/-) mice which induced severe inflammation. Furthrtmore, anti- inflammation factor such as IL-10 and TGF-beta Therefore, we conclude that apolipoprotein E knockout induced inflammatory responses related to microglia in neonatal mice brain via astrocytes.

• 出版日期2015