Neuroprotective effects of tamsulosin on intracerebral hemorrhage

作者：Suh Hong Jin^*; So Sung Min; Na Young Gil; Ko Il Gyu; Kim Sung Eun; Sung Yun Hee; Shin Mal Soon; Kim Chang Ju; Cho Young Sam; Kim Khae Hawn

来源：Neural Regeneration Research, 2011, 6(32): 2505-2510.

DOI：10.3969/j.issn.1673-5374.2011.32.005

• tamsulosin, intracerebral hemorrhage
• short-term memory
• apoptosis
• cell proliferation
• hippocampus
• neural regeneration

The alpha1 adrenoreceptor antagonist tamsulosin is primarily used to treat benign prostatic hypertrophy. In this study, we intragastrically administered rats with 0.01, 0.1 and 1 mg/kg tamsulosin to investigate the effects of tamsulosin on memory function, and hippocampal cell apoptosis and proliferation following intracerebral hemorrhage. Step-down avoidance task results showed that tamsulosin treatment markedly alleviated intracerebral hemorrhageinduced short-term memory impairment. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling results showed that tamsulosin treatment markedly suppressed intracerebral hemorrhage-induced caspase-3 expression in the hippocampal CA1 region and cell proliferation in the hippocampal dentate gyrus. Tamsulosin treatment at a dose of 0.01 mg/kg exhibited the most potent inhibitory effects on cell apoptosis and proliferation. These findings suggest that tamsulosin treatment facilitates the recovery of rat memory function by inhibiting hippocampal cell apoptosis and proliferation following intracerebral hemorrhage.

• 出版日期2011-11-15