Alcoholic liver disease: Clinical and translational research

作者：Neuman Manuela G; Malnick Stephen; Maor Yaakov; Nanau Radu M; Melzer Ehud; Ferenci Peter; Seitz Helmut K; Mueller Sebastian; Mell Haim; Samuel Didier; Cohen Lawrence B; Kharbanda Kusum K; Osna Natalia A; Ganesan Murali; Thompson Kyle J; McKillop Lain H; Bautista Abraham; Bataller Ramon; French Samuel W

来源：Experimental and Molecular Pathology, 2015, 99(3): 596-610.

DOI：10.1016/j.yexmp.2015.09.001

• Alcoholic liver disease
• Alcohol dehydrogenase
• Betaine
• CYP2E1
• Hepatocarcinogenesis
• Liver fibrosis
• Hepatitis B and C viral infection
• Human immunodeficiency virus
• Liver transplant

The present review spans a broad spectrum of topics dealing with alcoholic liver disease (ALD), including clinical research, translational research, pathogenesis and therapies. A special accent is placed on alcohol misuse, as alcohol is a legally commercialized and taxable product. Drinking alcohol, particularly from a young age, is a major health problem. Alcoholism is known to contribute to morbidity and mortality. A systematic literature search was performed in order to obtain updated data (2008-2015). The review is focused on genetic polymorphisms of alcohol metabolizing enzymes and the role of cytochrome p450 2E1 and iron in ALD. Alcohol-mediated hepatocarcinogenesis is also discussed in the presence or absence of co-morbidities such as viral hepatitis C as well as therapeutic the role of innate immunity in ALD-HCV. Moreover, emphasis was placed on alcohol and drug interactions, as well as liver transplantation for end-stage ALD. Finally, the time came to eradicate alcohol-induced liver and intestinal damage by using betaine.

• 出版日期2015-12
• 单位UCLA; NIH