Access to novel bicyclic fused gamma-butyrolactone using [3,3]-sigmatropic rearrangement and acid-lactonization sequence as key transformation

作者：Claveau Elise; Noirjean Erwan; Bouyssou Pascal; Coudert Gerard; Gillaizeau Isabelle^*

来源：Tetrahedron Letters, 2010, 51(23): 3130-3133.

DOI：10.1016/j.tetlet.2010.04.041

In this Letter, we wish to disclose a new strategy for the construction of substituted gamma-butyrolactones. The latter might not only be of potential interest in terms of biological activity and synthesis but also allow access to original heterocyclic scaffolds. According to previous study, efficient two-step sequence involving Eschenmoser-Claisen rearrangement and acid-lactonization reaction was successfully applied for the construction of original fused bicyclic gamma-butyrolactones based on an 1.4-oxazine core.

• 出版日期2010-6-9