Utility of cystatin C as a marker for the severity of aortic regurgitation in hypertensive patients

作者：Iida Masato^*; Yamamoto Mitsuru; Ishiguro Yuko S; Yamazaki Masatoshi; Ueda Norihiro; Honjo Haruo; Kamiya Kaichirou

来源：Clinica Chimica Acta, 2013, 425: 259-264.

DOI：10.1016/j.cca.2013.08.003

• Cystatin C
• Echocardiography
• CRP
• Vena contracta width
• Aortic regurgitation
• Hypertension

Background: cystatin c, a cathepsin inhibitor, is involved in the remodeling of human aortic valve and left ventricle (LV). Objective: Cystatin C may be related to the severity of aortic regurgitation (AR). %26lt;br%26gt;Methods: We measured cystatin C and CRP in hypertensive patients with mild-to-moderate AR (n = 120) and in those without AR (n = 128). Echocardiography was performed to assess the vena contracta width (the narrowest region of regurgitant jet, VCW) as a marker of the severity of AR, relative wall thickness as a marker of LV concentric remodeling, and the ratio of early peak mitral flow to early diastolic mitral annular velocity (E/e%26apos;) as an index of LV diastolic function. Glomerular filtration rate (GFR) was estimated using the MDRD methods. %26lt;br%26gt;Results: Cystatin C levels were greater in hypertensive patients with AR than in those without AR. A multiple linear regression analysis indicated cystatin C levels correlated with the VCW independent of GFR, body mass index, CRP, relative wall thickness, and E/e%26apos; in hypertensive patients with AR. %26lt;br%26gt;Conclusions: Cystatin C was associated with the severity of regurgitation independent of renal function body composition chronic inflammation LV remodeling and diastolic function in hypertensive patients with mild-to-moderate AR.

• 出版日期2013-10-21