Alzheimer's disease: Effects of beta-amyloid on mitochondria

作者：Tillement Laurent; Lecanu Laurent; Papadopoulos Vassilios^*

来源：Mitochondrion, 2011, 11(1): 13-21.

DOI：10.1016/j.mito.2010.08.009

• Alzheimer's disease
• beta-amyloid
• Mitochondria
• Mitochondrial dysfunction
• Neurodegenerative diseases

The impairment of the respiratory chain or defects in the detoxification system can decrease electron transfer efficiency, reduce ATP production, and increase reactive oxygen species (ROS) production by mitochondria. Accumulation of ROS results in oxidative stress, a hallmark of neurodegenerative diseases such as Alzheimer's disease (AD). beta-amyloid has been implicated in the pathogenesis of AD, and its accumulation may lead to degeneration of neuronal or non-neuronal cells. There is evidence that beta-amyloid interacts with mitochondria but little is known concerning the significance of this interaction in the physiopathology of AD. This review explores possible mechanisms of beta-amyloid-induced mitochondrial toxicity.

• 出版日期2011-1