Development of Voltammetric Method for the Determination of an Anticancer Drug, 5-Flurouracil, at a Multiwalled Carbon Nanotubes Paste Electrode

作者：Abbar Jyothi C^*; Shetti Nagaraj P; Nandibewoor Sharanappa T

来源：Synthesis and Reactivity in Inorganic Metal-Organic and Nano-Metal Chemistry, 2016, 46(6): 814-820.

DOI：10.1080/15533174.2014.989586

• 5-fluorouracil
• multiwalled carbon nanotubes
• voltammetry
• drug analysis
• oxidation

The voltammetric oxidation of an anticancer drug, 5-fluorouracil, was investigated at a multiwalled carbon nanotubes-paraffin oil paste electrode using cyclic and differential-pulse voltammetry. The oxidation process was irreversible over the pH range studied and exhibited a diffusion-controlled behavior. In the range of 0.1 x 10(6) to 5.0 x 10(6) M, the current measured by differential-pulse voltammetry presents a good linear property as a function of the concentration of 5-flurouracil with a detection limit of 3.94 x 10(8) M with good selectivity and sensitivity. The proposed method was successfully applied to 5-flurouracil determination in pharmaceutical and urine samples.

• 出版日期2016