Association of ADH2 and ALDH2 genetic polymorphisms with susceptibility to Parkinson's disease in a Chinese population

作者：Liu, Jidong; Sui, Shaohua; Xu, Lanyong; Lin, Kai; Zong, Jin; Yang, Yang; Wang, Hui^*

来源：International Journal of Clinical and Experimental Pathology, 2016, 9(9): 9436-9442.

• Parkinson's disease
• ADH2
• ALDH2
• polymorphism

Parkinson's disease is a common disorder of neurodegenerative diseases. The pathological process of this disease is involved in many environmental and genetic factors. In this study, we investigated the role of ADH2 Arg47His and ALDH2 Glu487Lys genetic variations in the risk of developing Parkinson's disease in a Chinese population. Between March 2013 and June 2015, 107 patients with Parkinson's disease and 192 healthy controls were recruited in our study. The ADH2 Arg47His and ALDH2 Glu487Lys polymorphisms were genotyped by polymerase chain reaction (PCR)-restriction fragment length polymorphism. Results of chi-square tests indicated a significant difference in the genotype distributions of ALDH2 Glu487Lys (chi(2) = 6.85, P = 0.03) between the patients with Parkinson's disease and the controls. We also performed unconditional logistic regression analyses, and observed that the GA genotype (OR = 1.71, 95% CI = 0.97-3.01; P = 0.05) and AA genotype (OR = 2.94, 95% CI = 0.85-10.67; P = 0.04) of ALDH2 Glu487Lys significantly elevated the risk of Parkinson's disease in comparison with the GG genotype. In addition, the A allele of ALDH2 Glu487Lys was significantly correlated with an increased risk of Parkinson's disease when compared to the G allele (OR = 1.79, 95% CI = 1.15-2.80; P = 0.01). However, the polymorphism in ADH2 Arg47His was not correlated with the risk of Parkinson's disease. In summary, this study indicates that ALDH2 Glu487Lys polymorphism influences the development of Parkinson's disease in the Chinese population studied here.

• 出版日期2016
• 单位聊城市人民医院