An efficient and straight forward synthesis of (5S)-1-benzyl-5-(1H-imidazol-1-ylmethyl)-2-pyrrolidinone (MM1): a novel antihypertensive agent

作者：Prasad Jagdish; Pathak Manoher Bhushan; Panday Sharad Kumar^*

来源：Medicinal Chemistry Research, 2012, 21(3): 321-324.

DOI：10.1007/s00044-010-9536-6

• Hypertension
• Angiotensin-II
• AT(1) antagonists
• MM1
• Mitsunobu reaction
• N-benzyl-5(S)-pyroglutaminol

(5S)-1-benzyl-5-(1H-imidazol-1-ylmethyl)-2-pyrrolidinone and its closely related analog was synthesized from (S)-pyroglutaminol and imidazole or substituted imidazole using Mitsunobu reaction as the key step.

• 出版日期2012-3