Aberrant expression of the apoptosis-related proteins BAK and MCL1 in T cells in multiple sclerosis

作者：Mandel Ilana; Paperna Tamar; Miller Ariel^*

来源：Journal of Neuroimmunology, 2012, 244(1-2): 51-56.

DOI：10.1016/j.jneuroim.2011.12.026

• Apoptosis
• Autoimmune
• BAK
• MCL1
• Multiple sclerosis
• Proteasome

Pathogenic T cells of multiple sclerosis (MS) patients have been suggested to be endowed with an increased resistance to apoptosis, contributing to their increased survival. We report herein increased levels of the antiapoptotic MCL1 protein and its half-life in activated lymphocytes of MS patients, which were not associated with differences in MCL1 RNA levels or with alterations in the expression levels of the known E3 ligases of MCL1-beta-TrCP and HUWE1. Concomitantly, the expression levels of the pro-apoptotic protein BAK were decreased in MS patients at relapse. These findings suggest the dysregulation of the apoptosis-related proteins MCL1 and BAK in MS.

• 出版日期2012-3