May T1 diabetes mellitus protect from asthma?

作者：Tosca Maria Angela; Silovestri Michela; D' Annunzio Giuseppe; Lorini Renata; Rossi Giovanni Arturo; Ciprandi Giorgio^*

来源：Allergologia et Immunopathologia, 2013, 41(5): 288-291.

DOI：10.1016/j.aller.2012.10.009

• Diabetes
• Asthma
• Allergic rhinitis
• Bronchoditation
• FEF25-75%

Background: Type 1 diabetes mellitus (T1DM) may be associated with allergy. It was previously reported that %26gt;20% of children with T1DM had allergic rhinitis (AR), but none was asthmatic. This finding was surprising as allergic rhinitis is frequently associated with asthma and asthma prevalence is about 10% of the general paediatric population. Thus, it was hypothesized that T1DM could protect from asthma. %26lt;br%26gt;Objectives: The aim of this preliminary study was to evaluate the pulmonary function and the response to bronchodilation testing in children, suffering from T1DM with associated AR, comparing them with a control group of children with AR alone. %26lt;br%26gt;Methods: Twenty children with T1DM and AR were compared with 59 children with AR alone; spirometry and bronchodilation testing were performed in all patients. %26lt;br%26gt;Results: There were no statistically significant differences in both %26quot;at baseline%26quot; and after bronchodilation testing about FVC, FEV1, and FEF25-75 values. However, changes in %26quot;post-bronchodilator%26quot; values of FEF25-75 (Delta FEF25-75) were significantly higher in children with AR alone than in children with T1DM and AR (p=0.04). %26lt;br%26gt;Conclusions: This preliminary study could sustain the hypothesis that T1DM in children suffering also from AR might exert a protective effect of preventing the possible evolution in asthma.

• 出版日期2013-10