Does cytokine signaling link sphingolipid metabolism to host defense and immunity against virus infections?

作者：Seo Young Jin; Alexander Stephen; Hahm Bumsuk^*

来源：Cytokine & Growth Factor Reviews, 2011, 22(1): 55-61.

DOI：10.1016/j.cytogfr.2010.12.001

• Sphingosine kinase
• S1P lyase
• Influenza virus
• Type I IFN
• TNF

Sphingosine 1-phosphate (S1P)-metabolizing enzymes regulate the level of bioactive sphingolipids that have curative potential. Recently, S1P-metabolizing enzymes such as sphingosine kinase 1 and SIP lyase were shown to regulate influenza virus replication and the virus-induced cytopathogenicity. The mechanism appeared to employ a JAK/STAT type 1 interferon signaling pathway that induces anti-viral status. Further, sphingosine analogs altered cytokine responses upon influenza virus infection. This article focuses on recent discoveries about the sphingolipid system that influences on host protection from viral virulence and the involvement of cytokine signaling in its underlying mechanisms. Deciphering the steps of this pathway could help us envision how the modulation of sphingolipid metabolism can be applied as a therapeutic approach to overcome infectious diseases.

• 出版日期2011-2