ADC mapping and T-1-weighted signal changes on post-injury MRI predict seizure susceptibility after experimental traumatic brain injury

作者：Frey Lauren^*; Lepkin Aaron; Schickedanz Alyssa; Huber Kendra; Brown Mark S; Serkova Natalie

来源：Neurological Research, 2014, 36(1): 26-37.

DOI：10.1179/1743132813Y.0000000269

• Epileptogenesis
• Fluid percussion injury
• Kainate
• MRI
• Post-traumatic epilepsy

Objective: Post-traumatic epilepsy (PTE) is a serious complication of traumatic brain injury (TBI). This study is designed to determine the feasibility of using multiparametric MRI endpoints to predict differences in seizure susceptibility after experimental TBI.
Methods: MRI imaging and behavioral measurements were performed at multiple time points after lateral fluid percussion injury (FPI) in rats. Seizure susceptibility was determined by video-electroencephalogram (EEG) monitoring and off-line signal analysis after chemoconvulsant challenge.
Results: Multiple MRI endpoints, including measures of injury-related brain swelling (normalized interhemispheric volume difference, NIVD) and T1-weighted signal change with contrast enhancement (a measure of blood-brain barrier disruption, BBBD), reliably distinguished between injured and sham-injured animals at 72 hours after injury. ADC (apparent diffusion coefficient) values (a measure of water diffusivity) in injured cortex at 72 hours and 1 week after injury, BBBD in injured cortex at 72 hours after injury and NIVD at 72 hours after injury were significantly correlated with EEG-based measures of seizure susceptibility to chemoconvulsant challenge at 3 months after injury.
Conclusions: The correlations between our MRI quantitative endpoints and EEG-based measures of seizure susceptibility to chemoconvulsant challenge in injured animals versus sham-injured animals support the feasibility of these MRI endpoints as potential biomarkers for post-traumatic epileptogenesis.

• 出版日期2014-1