A molecular epidemiological study targeting the glycoprotein gene of rabies virus isolates from China

作者：Meng Sheng Li; Yan Jia Xin^*; Xu Ge Lin; Nadin Davis Susan A; Ming Ping Gang; Liu Sheng Ya; Wu Jie; Ming He Tian; Zhu Feng Cai; Zhou Dun Jin; Xiao Qi You; Dong Guan Mu; Yang Xiao Ming

来源：Virus Research, 2007, 124(1-2): 125-138.

DOI：10.1016/j.virusres.2006.10.011

• rabies virus
• molecular epidemiology
• G gene
• China

A group of 31 rabies viruses (RABVs), recovered primarily from dogs, one deer and one human case, were collected from various areas in China between 1989 and 2006. Complete G gene sequences determined for these isolates indicated identities of nucleotide and amino acid sequences of > 87% and 93.8%, respectively. Phylogenetic analysis of these and some additional Chinese isolates clearly supported the placement of all Chinese viruses in Lyssavirus genotype I and divided all Chinese isolates between four distinct groups (I-IV). Several variants identified within the most commonly encountered group I were distributed according to their geographical origins. A comparison of representative Chinese viruses with other isolates retrieved world-wide indicated a close evolutionary relationship between China group I and 11 viruses and those of Indonesia while China group III viruses formed an outlying branch to variants from Malaysia and Thailand. China group IV viruses were closely related to several vaccine strains. The predicted glycoprotein sequences of these RABVs variants are presented and discussed with respect to the utility of the anti-rabies biologicals currently employed in China.

• 出版日期2007-3
• 单位中国食品药品检定研究院; 江苏省疾病预防控制中心